[轉發材料系演講]2015/2/13陳東風教授演講公告
消息來源：材料系
截止日期：2015-02-13
題 目：Reversing Blinding Through a Regenerative Approach
時間：2015/2/13 (星期五)上午十點
地 點：臺灣大學工學院綜合大樓 228 室
演講者：陳東風教授
美國哈佛大學醫學院眼科
Dong Feng Chen, M.D., Ph.D.
Schepens Eye Research Institute
Massachusetts Eye and Ear
Department of Ophthalmology
Harvard Medical School
At a certain point in mammalian development, neurons in the central nervous system
lose their ability to grow axons, which leads to catastrophic consequence and
permanent functional deficit after injury. Activation of axonal growth program is a
critical step in successful nerve regeneration following injury. Yet the molecular
mechanisms that orchestrate this transition are not fully understood. Here we report
the identification of essential players that maintain the activate growth status of the
optic nerve during development and regeneration. The fact that the axon growth
mechanism is directly regulated by a secretory factor suggests the possibility of
pharmacological manipulation to promote axon regeneration and reverse the loss of
vision. Because the optic nerve has long served as a standard model for CNS studies,
our results are application for treating injuries in the brain and spinal cord and
promoting functional recovery after CNS injury in human patients.
時間：2015/2/13 (星期五)上午十點
地 點：臺灣大學工學院綜合大樓 228 室
演講者：陳東風教授
美國哈佛大學醫學院眼科
Dong Feng Chen, M.D., Ph.D.
Schepens Eye Research Institute
Massachusetts Eye and Ear
Department of Ophthalmology
Harvard Medical School
At a certain point in mammalian development, neurons in the central nervous system
lose their ability to grow axons, which leads to catastrophic consequence and
permanent functional deficit after injury. Activation of axonal growth program is a
critical step in successful nerve regeneration following injury. Yet the molecular
mechanisms that orchestrate this transition are not fully understood. Here we report
the identification of essential players that maintain the activate growth status of the
optic nerve during development and regeneration. The fact that the axon growth
mechanism is directly regulated by a secretory factor suggests the possibility of
pharmacological manipulation to promote axon regeneration and reverse the loss of
vision. Because the optic nerve has long served as a standard model for CNS studies,
our results are application for treating injuries in the brain and spinal cord and
promoting functional recovery after CNS injury in human patients.