Title: Welcome to the age of protein cinematography

Speaker: Dr. Ming-Daw Tsai (Institute of Biological Chemistry, Academia Sinica)

蔡明道院士 (本院生物化學研究所)

Time: 3:30 PM, October 17 (Thursday), 2024

Place: Dr. Poe Lecture Hall, IAMS (本所浦大邦講堂臺大校園內)

Contact: Prof. Manuel Maestre-Reyna 馬佐仲助理教授

 

Brief Resume: Ming-Daw Tsai received B.S. degree from National Taiwan University (1972) and Ph.D. from Purdue University (1978). He served in the faculty of the Dept of Chemistry and Biochemistry, The Ohio State University from 1981 and later became Kimberly Professor of Chemistry. At OSU he also served as director of the Campus Chemical Instrument Center from 1993-2006, and founding director of the Chemistry-Biology Interface Training Program from 1995-2003. He moved to Genomics Research Center of Academia Sinica in late 2003, then served as Director of Institute of Biological Chemistry during 2006-2014. His research interests include mechanistic enzymology of phosphoryl transfer enzymes including DNA polymerases, kinases and phospholipases, and structure-function relationship of proteins in DNA damage response and cancer signaling, including ankyrin repeat proteins, FHA domain proteins, and recently DNA photolyases. He probes mechanistic problems by applying emerging methodologies in structural biology, including NMR, X-ray crystallography, MS, and recently cryo-EM and X-ray free electron laser (XFEL), leading to over 300 publications. He initiated and oversaw the Taiwan Protein Project during 2016-23. In 2018 he led the establishment of Academia Sinica Cryo-EM Center (ASCEM). He was elected to Fellow, American Association for the Advancement of Science (AAAS, 1992), Academician, Academia Sinica (2012), and Fellow, The World Academy of Science (TWAS, 2014).