臺大化學系 今日(11/12)學術演講訊息-Prof. Kenneth J. Shea
截止日期：2012-11-12
日期：2012/11/12（Mon.）
時間：自15時30分至17時00分
演講地點(地址): 化學系潘貫講堂（Pan-Kuan Lecture Hall, Dept. of Chemistry）
演講者: Prof. Kenneth J. Shea
演講者職稱：Professor
演講者服務單位：Department of Chemistry, University of California, USA
演講題目：“Plastic Antibodies”. Abiotic Receptors for Peptides, Proteins and Carbohydrates.
【Abstract】
Just as medicinal chemists routinely design and synthesize small molecules to target the active site of a single protein in the proteome, we suggest that advances in polymer synthesis, structural biology and nanotechnology have progressed to the point where we can begin to design synthetic polymer nanoparticles (NPs) with antibody-like affinity and selectivity for targeted biomacromolecules. The talk will describe abiotic protein/peptide and carbohydrate affinity agents. These agents, synthetic polymer NP hydrogels, are formulated with functional groups complementary to the biomacromolecule target. We use an iterative process to improve binding affinity by optimizing the composition and proportion of functional monomers. Unique to these materials is that their affinity can be “turned off” simply by lowering the solution temperature, a strategy we have exploited in protein purification via “catch and release”.
The talk will be concerned with an exploration of new targets and applications for abiotic polymer nanoparticles. In addition we will describe biological and bioanalytical techniques to characterize NP-biomacromolecule binding to develop insight into the fundamentals of binding affinity.
Journal of Materials Chemistry, 2011, 20, 3517-3521
時間：自15時30分至17時00分
演講地點(地址): 化學系潘貫講堂（Pan-Kuan Lecture Hall, Dept. of Chemistry）
演講者: Prof. Kenneth J. Shea
演講者職稱：Professor
演講者服務單位：Department of Chemistry, University of California, USA
演講題目：“Plastic Antibodies”. Abiotic Receptors for Peptides, Proteins and Carbohydrates.
【Abstract】
Just as medicinal chemists routinely design and synthesize small molecules to target the active site of a single protein in the proteome, we suggest that advances in polymer synthesis, structural biology and nanotechnology have progressed to the point where we can begin to design synthetic polymer nanoparticles (NPs) with antibody-like affinity and selectivity for targeted biomacromolecules. The talk will describe abiotic protein/peptide and carbohydrate affinity agents. These agents, synthetic polymer NP hydrogels, are formulated with functional groups complementary to the biomacromolecule target. We use an iterative process to improve binding affinity by optimizing the composition and proportion of functional monomers. Unique to these materials is that their affinity can be “turned off” simply by lowering the solution temperature, a strategy we have exploited in protein purification via “catch and release”.
The talk will be concerned with an exploration of new targets and applications for abiotic polymer nanoparticles. In addition we will describe biological and bioanalytical techniques to characterize NP-biomacromolecule binding to develop insight into the fundamentals of binding affinity.
Journal of Materials Chemistry, 2011, 20, 3517-3521