[原分所] May 21 IAMS Lecture Announcement--Prof. Chin-Lin Guo 郭青齡教授
消息來源：化學系辦
截止日期：2013-05-21
IAMS Lecture Announcement
中研院原分所演講公告
Title: Mechanics-driven self-organization in tissue-scale tubulogenesis
Speaker: Prof. Chin-Lin Guo 郭青齡教授 (Bioengineering and Applied Physics, California Institute of Technology, USA)
Time: 1:30 PM, May 21 (Tuesday)
Place: Dr. Poe Lecture Hall, IAMS (浦大邦講堂 臺大校園內)
Contact: Dr. Mei-Yin Chou 周美吟所長
Abstract: Many living systems possess an amazing ability to self-organize various structures without external guidance. Such self-organization, however, often requires specific biochemical stimulations. Here, we study whether cells can use mechanical forces alone to create long-range correlation in multicellular morphogenesis such as tubule formation. In contrast to the conventional thoughts that cells make decisions by chemical stimulations or by genetic programming, we show that a long-range morphological decision (~ 600 microns) can be made by mechanical forces alone. Such decision making process allows cells to self-organize long tubules at the organ scales (~ centimeters) without preexisting spatial cues from biochemical factors or scaffolds. These findings can be explained by simple physical models and provide a novel framework for the engineering of functional organs.
中研院原分所演講公告
Title: Mechanics-driven self-organization in tissue-scale tubulogenesis
Speaker: Prof. Chin-Lin Guo 郭青齡教授 (Bioengineering and Applied Physics, California Institute of Technology, USA)
Time: 1:30 PM, May 21 (Tuesday)
Place: Dr. Poe Lecture Hall, IAMS (浦大邦講堂 臺大校園內)
Contact: Dr. Mei-Yin Chou 周美吟所長
Abstract: Many living systems possess an amazing ability to self-organize various structures without external guidance. Such self-organization, however, often requires specific biochemical stimulations. Here, we study whether cells can use mechanical forces alone to create long-range correlation in multicellular morphogenesis such as tubule formation. In contrast to the conventional thoughts that cells make decisions by chemical stimulations or by genetic programming, we show that a long-range morphological decision (~ 600 microns) can be made by mechanical forces alone. Such decision making process allows cells to self-organize long tubules at the organ scales (~ centimeters) without preexisting spatial cues from biochemical factors or scaffolds. These findings can be explained by simple physical models and provide a novel framework for the engineering of functional organs.