[原分所] June 20 IAMS Lecture Announcement--Prof. Kuan Wang 王寬院士
消息來源：原分所
截止日期：2013-06-20
IAMS Lecture Announcement中研院原分所演講公告
Title: Nanomechanics of intrinsically disordered proteins: interplay of force, form and function
Speaker: 王寬院士 (中研院生化所)Prof. Kuan Wang (Inst. of Biological Chemistry, Academia Sinica)
Time: 3:30 PM, June 20 (Thursday)
Place: Dr. Poe Lecture Hall, IAMS (原分所浦大邦講堂 臺大校園內)
Contact: Dr. Kaito Takahashi 高橋開人博士
【Abstract】
Proteins and protein domains that lack unique folds are essential participants in a variety of biological processes. How these intrinsically disordered proteins in catalysis, in the assembly of complexes and in cellular signaling are emerging themes in structural biology. As part of long term interest of investigating the structural biology and function of titin and nebulin, two of the largest proteins in human proteome that we discovered some years ago, we have established a technical platform to understand the interplay between the force, form and function of the intrinsically disordered regions of these elastic proteins and made some major conceptual advances. The key concept is that the nanomechanical properties of IDP are critically important in how they function in the signaling pathways and force signals are transduced to biochemical and cellular processes. The technical platform includes protein engineering of polyproteins with built-in force handles, conformational studies in solution and on surface by NMR, force microscopy and single molecule imaging by AFM, simulated molecular dynamics, adaptive data analysis technique and other computational techniques. The structural transitions of force events during protein stretching, especially those of IDP, provide unique insights in the dynamics signaling pathways under mechanical stress.
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Dr. Kuan Wang is currently the Director of Nanomedicine Program and Distinguished Research Fellow at the Institute of Biological Chemistry and Institute of Physics, at Academia Sinica, Taiwan.
Dr. Wang\'s research has made significant contributions to the study of muscle biology and cell motility, including the discovery and naming of five new cytoskeletal proteins (filamin, titin, nebulin, P235 (talin) and nebulette) important in assembly, regulation and dysfunction of the cytomatrix in cardiac, skeletal and smooth muscles and in non-muscle cells. Three drug-discovery projects are under development: the rational design of drug toward intrinsically disordered, elastic protein domains in signaling proteins; the application of micro-patterned skeletal and cardiac cells on elastic substrates as cell-based platforms for drug discovery, and nano-patterned motile proteins on fabricated device as molecule-based platforms for drug discovery, and the application of Fast System Control technique to development combinatorial drugs for cardiovascular, cancer and infectious diseases.
Title: Nanomechanics of intrinsically disordered proteins: interplay of force, form and function
Speaker: 王寬院士 (中研院生化所)Prof. Kuan Wang (Inst. of Biological Chemistry, Academia Sinica)
Time: 3:30 PM, June 20 (Thursday)
Place: Dr. Poe Lecture Hall, IAMS (原分所浦大邦講堂 臺大校園內)
Contact: Dr. Kaito Takahashi 高橋開人博士
【Abstract】
Proteins and protein domains that lack unique folds are essential participants in a variety of biological processes. How these intrinsically disordered proteins in catalysis, in the assembly of complexes and in cellular signaling are emerging themes in structural biology. As part of long term interest of investigating the structural biology and function of titin and nebulin, two of the largest proteins in human proteome that we discovered some years ago, we have established a technical platform to understand the interplay between the force, form and function of the intrinsically disordered regions of these elastic proteins and made some major conceptual advances. The key concept is that the nanomechanical properties of IDP are critically important in how they function in the signaling pathways and force signals are transduced to biochemical and cellular processes. The technical platform includes protein engineering of polyproteins with built-in force handles, conformational studies in solution and on surface by NMR, force microscopy and single molecule imaging by AFM, simulated molecular dynamics, adaptive data analysis technique and other computational techniques. The structural transitions of force events during protein stretching, especially those of IDP, provide unique insights in the dynamics signaling pathways under mechanical stress.
-------------------------------------------------
Dr. Kuan Wang is currently the Director of Nanomedicine Program and Distinguished Research Fellow at the Institute of Biological Chemistry and Institute of Physics, at Academia Sinica, Taiwan.
Dr. Wang\'s research has made significant contributions to the study of muscle biology and cell motility, including the discovery and naming of five new cytoskeletal proteins (filamin, titin, nebulin, P235 (talin) and nebulette) important in assembly, regulation and dysfunction of the cytomatrix in cardiac, skeletal and smooth muscles and in non-muscle cells. Three drug-discovery projects are under development: the rational design of drug toward intrinsically disordered, elastic protein domains in signaling proteins; the application of micro-patterned skeletal and cardiac cells on elastic substrates as cell-based platforms for drug discovery, and nano-patterned motile proteins on fabricated device as molecule-based platforms for drug discovery, and the application of Fast System Control technique to development combinatorial drugs for cardiovascular, cancer and infectious diseases.